Dr. Lars Redecke



Lars Redecke

Head of Junior Research Group
"Structural Infection Biology applying new Radiation Sources (SIAS)"
der Universitäten Lübeck und Hamburg

Tel: +4940 / 8998 - 5389, Fax: - 4747
E-Mail: Redecke@chemie.uni-hamburg.de
             Redecke@biochem.uni-luebeck.de



Scientific Career

Studies of chemistry at the university of Hamburg; diploma thesis (2000) and PhD thesis (2005) in the department of chemistry at the university of Hamburg; Postdoc at University Medical Center Hamburg-Eppendorf, department for macromolecular strutrural analysis (2003 - 2006); Postdoc in the department of biochemistry and molecular biology at the university of Hamburg (2007-2008); Postdoc of Max-Planck-Group for structural molecular biology (2009);

Since 01.12.2009 head of the joint junior research group "Structural Infection Biology Using New Radiation Sources (SIAS)" of the universities of Hamburg and Lübeck.

Cooperations

Alfred-Wegener Institut für Polar und Meeresforschung, Helgoland (Dr. R. Saborowski); Umweltforschungszentrum (UFZ) Leipzig (PD Dr. M. von Bergen); Altagen Inc. (Ontario/Canada); Robert-Koch-Institut, Berlin (Dr. M. Baier); EMBL Outstation, Hamburg (Dr. W. Meyer-Klaucke, Dr. D.I. Svergun); Institut für Angewandte Physik, Universität Hamburg (Prof. M. Rübhausen); Centro de Estudio de Proteínas, Facultad de Biología, Universidad de la Habana, Cuba (Prof. María de los Ángeles Chávez);Institut für Organische Chemie, Universität Hamburg (Prof. B. Meyer); Max-Planck-Arbeitsgruppen für Strukturelle Molekularbiologie, Hamburg (Prof. E. Mandelkow); Institut für Biochemie, Universität zu Lübeck (Prof. R. Hilgenfeld); Institut für Virologie und Zellbiologie, Universität zu Lübeck (Prof. N. Tautz); Heinrich-Pette-Institut, Hamburg (Prof. H. Will); Zentrum für innere Medizin, AG Hepatologie, Universitätsklinikum Hamburg-Eppendorf (Dr. M. Dandri).

Publications



2014

Tepper K, Biernat J, Kumar S, Wegmann S, Timm T, Hübschmann S, Redecke L, Mandelkow EM, Müller DJ, Mandelkow E.
Oligomer Formation of Tau Hyperphosphorylated in Cells.
J Biol Chem. 2014 Oct 22.

 

Gati C, Bourenkov G, Klinge M, Rehders D, Stellato F, Oberthür D, Yefanov O, Sommer BP, Mogk S, Duszenko M, Betzel C, Schneider TR, Chapman HN, Redecke L.
Serial crystallography on in vivo grown microcrystals using synchrotron radiation.
IUCrJ (2014) 1, 87-94.

 

Hehemann JH, Law A, Redecke L, Boraston AB.
The structure of RdDddP from Roseobacter denitrificans reveals that DMSP lyases in the DddP-family are metalloenzyme.

PLoS One.2014 Jul 23;9(7):e103128.

 

2013

Johansson LC, Arnlund D, Katona G, White TA, Barty A, DePonte DP, Shoeman RL, Wickstrand C, Sharma A, Williams GJ, Aquila A, Bogan MJ, Caleman C, Davidsson J, Doak RB, Frank M, Fromme R, Galli L, Grotjohann I, Hunter MS, Kassemeyer S, Kirian RA, Kupitz C, Liang M, Lomb L, Malmerberg E, Martin AV, Messerschmidt M, Nass K, Redecke L, Seibert MM, Sjöhamn J, Steinbrener J, Stellato F, Wang D, Wahlgren WY, Weierstall U, Westenhoff S, Zatsepin NA, Boutet S, Spence JC, Schlichting I, Chapman HN, Fromme P, Neutze R.
Structure of a photosynthetic reaction centre determined by serial femtosecond crystallography.
Nat Commun. 2013;4:2911.

 

Elmallah MI, Borgmeyer U, Betzel C, Redecke L.
Impact of methionine oxidation as an initial event on the pathway of human prion protein conversion.
Prion. 2013 Oct 9;7(5).

Redecke L, Nass K, Deponte DP, White TA, Rehders D, Barty A, Stellato F, Liang M, Barends TR, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Aquila A, Arnlund D, Bajt S, Barth T, Bogan MJ, Caleman C, Chao TC, Doak RB, Fleckenstein H, Frank M, Fromme R, Galli L, Grotjohann I, Hunter MS, Johansson LC, Kassemeyer S, Katona G, Kirian RA, Koopmann R, Kupitz C, Lomb L, Martin AV, Mogk S, Neutze R, Shoeman RL, Steinbrener J, Timneanu N, Wang D, Weierstall U, Zatsepin NA, Spence JC, Fromme P, Schlichting I, Duszenko M, Betzel C, Chapman HN.
Natively inhibited
Trypanosoma brucei cathepsin B structure determined using an x‑ray laser
.
Science. 2013 Jan 11;339(6116):227-30


2012

García-Fernández R, Pons T, Meyer A, Perbandt M, González-González Y, Gil D, de Los Angeles Chávez M, Betzel C, Redecke L.
Structure of the recombinant BPTI/Kunitz-type inhibitor rShPI-1A from the marine invertebrate Stichodactyla helianthus.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1289-93.


García-Fernández R, Pons T, Perbandt M, Valiente PA, Talavera A, González-González Y, Rehders D, Chávez MA, Betzel C, Redecke L.
Structural insights into serine protease inhibition by a marine invertebrate BPTI Kunitz-type inhibitor.


Sébastien Boutet, Lukas Lomb,, Garth J. Williams, Thomas R.M. Barends,, Andrew Aquila, R. Bruce Doak, Uwe Weierstall, Daniel P. DePonte, Jan Steinbrener,, Robert L. Shoeman,, Marc Messerschmidt, Anton Barty, Thomas A. White, Stephan Kassemeyer,, Richard A. Kirian, M. Marvin Seibert, Paul A. Montanez, Chris Kenney, Ryan Herbst, Philip Hart, Jack Pines, Gunther Haller, Sol M. Gruner,, Hugh T. Philipp, Mark W. Tate, Marianne Hromalik, Lucas J. Koerner0, Niels van Bakel, John Morse, Wilfred Ghonsalves, David Arnlund, Michael J. Bogan, Carl Caleman, Raimund Fromme, Christina Y. Hampton, Mark S. Hunter, Linda Johansson, Gergely Katona, Christopher Kupitz, Mengning Liang, Andrew V. Martin, Karol Nass, Lars Redecke, Francesco Stellato, Nicusor Timneanu, Dingjie Wang, Nadia A. Zatsepin, Donald Schafer, James Defever, Richard Neutze, Petra Fromme, John C.H. Spence, Henry N. Chapman, and Ilme Schlichting.
High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography.


Koopmann R*, Cupelli K*, Redecke L*, Nass K, Deponte DP, White TA, Stellato F, Rehders D, Liang M, Andreasson J, Aquila A, Bajt S, Barthelmess M, Barty A, Bogan MJ, Bostedt C, Boutet S, Bozek JD, Caleman C, Coppola N, Davidsson J, Doak RB, Ekeberg T, Epp SW, Erk B, Fleckenstein H, Foucar L, Graafsma H, Gumprecht L, Hajdu J, Hampton CY, Hartmann A, Hartmann R, Hauser G, Hirsemann H, Holl P, Hunter MS, Kassemeyer S, Kirian RA, Lomb L, Maia FR, Kimmel N, Martin AV, Messerschmidt M, Reich C, Rolles D, Rudek B, Rudenko A, Schlichting I, Schulz J, Seibert MM, Shoeman RL, Sierra RG, Soltau H, Stern S, Strüder L, Timneanu N, Ullrich J, Wang X, Weidenspointner G, Weierstall U, Williams GJ, Wunderer CB, Fromme P, Spence JC, Stehle T, Chapman HN, Betzel C, Duszenko M.
In vivo crystallization opens new routes in structural biology.
Nat Methods
. 2012 Jan 29;9(3):259-62.

2010

A. Andreyeva, I. Leshchyns'ka, M. Knepper, C. Betzel, L. Redecke, V. Sytnyk, M. Schachner. CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex. PLoS One 5:e12018 (2010).

D. Georgieva, L. Redecke, M. von Bergen, N. Genov, C. Betzel. Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein. Protein Pept. Lett.17:399-404 (2010).

2009

D. Georgieva, L. Redecke, M. von Bergen, N. Genov, C. Betzel. Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein. Protein Pept. Lett. (2009).

L. Redecke, S. Binder, M.I.Y. Elmallah, R. Broadbent, C. Tilkorn, B. Schulz, P. May, A. Goos, A. Eich, M. Rübhausen, Ch. Betzel. UV light induced conversion and aggregation of prion proteins. Free Radic. Biol. Med. 15:1353-1361 (2009).

D. Rehders, B. Claasen,  L. Redecke, A. Buschke, C. Reibe, N. Jehmlich, M. von Bergen, Ch. Betzel, B. Meyer.  Octapeptide NMHRYPNQ of the cellular prion protein (PrPC) inhibits aggregation and is a potential key for understanding prion prion interactions.J. Mol. Biol. 392:198-207 (2009).

2008

L. Redecke*, J.H. Hehemann*, J. Murugaiyan, M. von Bergen, Ch. Betzel, R. Saborowski. Autoproteolytic stability of a trypsin from the marine crab Cancer pagurus. Biochem. Biophys. Res. Commun. 370:566-571 (2008).

2007

J.H. Hehemann, L. Redecke, M. Perbandt, R. Saborowski, Ch. Betzel. Crystallization and preliminary X-ray diffraction studies of trypsin-like proteases from the gastric fluid of the marine crab Cancer pagurus. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 63:242-245 (2007)

G. Zoldák, L. Redecke, D.I. Svergun, P.V. Konarev, S. Voertler, H. Dobbek, E. Sedlák, M. Sprinzl. Release factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalo-rimetric studies. Nuc. Acids. Res. 35:1343-1353 (2007)

L. Redecke, M.A. Brehm, R. Bredehorst. Cloning and characterization of dihydrofolate reductase from a facultative alkaliphilic and halotolerant Bacillus strain. Extremophiles 11:75-83 (2007)

L. Redecke, M. von Bergen, J. Clos, P.V. Konarev, D.I. Svergun, U.E.A. Fittschen, J.A.C. Broekaert, O. Bruns, D. Georgieva, E. Mandelkow, N. Genov, Ch. Betzel. Structural characterization of β-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro. J. Struct. Biol. 157:308-320 (2007)

2006

D. Georgieva, D. Schwark, M. von Bergen, L. Redecke, N. Genov, Ch. Betzel. Interactions of recombinant prions with compounds of therapeutical significance. Biochem. Biophys. Res. Commun. 344:463-470 (2006)

2005

L. Redecke, W. Meyer-Klaucke, M. Koker, J. Clos, D. Georgieva, N. Genov, H. Echner, H. Kalbacher, M. Perbandt, R. Bredehorst, W. Voelter, Ch. Betzel. Comparative analysis of the human and chicken prion protein copper binding regions at pH 6.5. J. Biol. Chem. 280:13987-13992 (2005)

2004

D. Georgieva, W. Rypniewski, H. Echner, M. Perbandt, M. Koker, J. Clos, L. Redecke, R. Bredehorst, W. Voelter, N. Genov, Ch. Betzel. Synthetic human prion protein octapeptide repeat binds to the proteinase K active site. Biochem. Biophys. Res. Commun. 325:1406-1411 (2004)

D. Georgieva, M. Koker, L. Redecke, M. Perbandt, J. Clos, R. Bredehorst, N. Genov, Ch. Betzel. Oligomerization of the proteolytic products is an intrinsic property of prion proteins. Biochem. Biophys. Res. Commun. 323:1278-1286 (2004)